中文摘要：

目的探讨HIV/HCV共同感染者脂肪肝的发生率和独立危险因素分析。方法选取102例HIV/HCV共同感染者,通过彩超检查是否存在脂肪肝,分析所有患者的性别、感染途径、体质指数（BMI）、高效抗反转录病毒治疗（HAART）方案和持续时间、CD4＋T淋巴细胞计数、空腹血糖、血脂、肝肾功能、HCV-RNA定量值和HCV-RNA阳性率,采用Logistic回归分析HIV/HCV共同感染者脂肪肝的独立危险因素。结果在102例HIV/HCV共同感染者中,21例（20.6%）存在脂肪肝。Logistic回归多变量分析发现脂肪肝的独立危险因素包括：高总胆固醇（TG）血症（OR=1.76,P=0.010）、低高密度脂蛋白（HDL）血症（OR=0.14,P=0.049）和HAART持续时间（OR=1.03,P=0.006）;未发现患者的性别、感染途径、BMI、肝肾功能、HAART方案、CD4＋T淋巴细胞计数、HCV-RNA定量值和HCV-RNA阳性率与脂肪肝的发生相关。结论 HIV/HCV共同感染者中脂肪肝的发生率为20.6%;高TG血症、低HDL血症和HAART治疗持续时间是脂肪肝发生的独立预测因素。

英文摘要：

Objective To explore the prevalence and independent risk factors of hepatic steatosis in HIV/HCV co-infected patients. Methods We performed a retrospective study.The prevalence of hepatic steatosis in HIV/HCV co-infected patients was evaluated by ultrasound examination.Risk factors including gender,BMI,duration of HAART,HAART regimen,CD4 cell count,fasting plasma glucose,metabolic syndromes,hyperlipemia,HCV-RNA and liver functions were evaluated by logistic regression analysis. Results We retrospectively studied the clinical data of HIV/HCV co-infected patients and find that 21（20.6%） of them were diagnosed as hepatic steatosis.Multivariate logistic regression analyses revealed that the following risk factors were associated with hepatic steatosis：high triglycerides（OR=1.76,P=0.010）,low HDL（OR=0.14,P=0.049） and durations of HAART（OR=1.03,P=0.006）.The following factors,including gender,BMI,ART regimen,CD4 cell count,fasting plasma glucose,HCV-RNA and liver functions were not associated with hepatic steatosis. Conclusion Prevalence of hepatic steatosis in HIV/HCV co-infected patients is 20.6%.High triglycerides levels,low HDL levels and HAART durations are independent risk factors of hepatic steatosis in HIV/HCV co-infected patients.