中文摘要：

移植后造血干细胞（HSC）的归巢和植入直接影响移植的效果,探索移植后骨髓中HSC的空间分布、定位和与周围微环境的相互作用具有重要意义.由于骨髓腔密闭且被厚而不透光的密质骨包绕,使通过体内直接追踪移植后HSC遇到很大挑战.近期,研究者们使用不同的创新方法体内直接观察移植后骨髓中HSC的空间分布及其与周围微环境的作用关系,文章对此进行了总结.

英文摘要：

Homing and engraftment of transplanted hematopoietic stem cells （HSCs） can directly influence the effect of the transplantation.Exploration on its spatial distribution,location and interaction with the bone marrow （BM） microenvironment is great significance.Since the BM cavity is closed and surrounded by thick compact bone,it makes a colossal challenge to track the transplanted HSCs in vivo directly.Recently,researchers used different innovative methods to observe the spatial distribution and interaction with the BM microenvironment of the transplanted HSCs.The present review summarized the progress in the HSCs transplantation.