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中文摘要：
探讨了重离子束辐照后荷颊囊癌金黄地鼠血清中微量元素含量的变化趋势。采用0,4,6,8和12 Gy剂量的12C6＋离子束对荷颊囊癌金黄地鼠辐照治疗后28 d取血,应用原子吸收光谱仪火焰法测定血清中Fe,Cu,Zn,Mg和Ca 5种微量元素的含量。金黄地鼠成瘤后,血清中微量Cu,Zn,Ca和Mg元素含量下降,均明显低于正常组（P〈0.05）;不同剂量的重离子束辐照后28 d,血清中5种微量元素在低剂量时均呈现继续下降趋势,在6或8 Gy时恢复到正常组水平,到12 Gy再呈降低的趋势,存在一定的剂量-反应关系。重离子束辐照影响荷颊囊癌金地鼠血清微量元素的含量,具有一定的临床意义。
英文摘要：
To study the trend of the changes of trace elements in serum of golden hamster with cheek pouch carcinoma after irradiation by heavy ion beam,the cheek pouch carcinoma of golden hamster was exposed to different doses of heavy ion beam,after 4 weeks,the contents of Cu,Zn,Fe,Mg and Ca in serum were detected by flame method of Atomic Absorption Spectrometer.The contents of Cu,Zn,Ca and Mg in experimental groups with cheek pouch carcinoma were significantly lower than that of the normal group（P0.05）.After irradiated by 0,4,6,8,12 Gy heavy ion beam,the 4 Gy group showed a tendency downward,when the irradiation dose reached 6 Gy,the contents of Fe,Zn were increased,and decreased at 12 Gy.While Cu,Ca and Mg content of 8 Gy group rose to the highest,and decreased at 12 Gy.All of the results showed a dose-reaction relationship（P0.05）.The irradiation of heavy ion beam maybe significantly affect the content of trace elements in serum of golden hamster with cheek pouch carcinoma.
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