中文摘要：

骨组织细胞包括成骨细胞、破骨细胞、骨细胞和骨衬细胞。在体内生理条件下，流体剪切力可能是这些细胞受到的最主要的力学刺激。近年来对流体剪切力影响骨组织细胞的研究取得了较大的进展，相关研究主要集中在流体剪切力引起骨组织细胞的细胞内信号分子、细胞内钙信号、细胞间隙连接和细胞骨架系统改变这几个方面，同时，流体剪切力会引起骨组织细胞间的相互作用的改变。本文就这些方面的重要研究内容做简要综述。

英文摘要：

Bone cells include osteoblasts, osteoclasts, osteocytes and bone lining cells. In vivo physiological conditions, the most important mechanical stimulation that bone cells underwent is fluid shear stress. In recent years, research on effects of fluid shear stress on bone cells has made great progress. Current experiments are focusing on the changes in signal molecules, intracellular calcium, gap junction and cell cytoskeleton. Also fluid shear stress could cause some changes in the interaction of bone cells. This paper reviews the progress of the studies in this field.