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一步PCR法对人Toll样受体4基因的快速定点突变及突变体表达载体的构建
  • ISSN号:1001-9030
  • 期刊名称:中华实验外科杂志
  • 时间:0
  • 页码:1173-1174
  • 分类:R459.9[医药卫生—治疗学;医药卫生—临床医学]
  • 作者机构:[1]Institute of Digestive Surgery and Department of Colorectal Surgery, and State Key Laboratory of Biotherapy, West China Hospital, Siehuan University, Chengdu 610041, China, [2]Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, China
  • 相关基金:Project supported by the National Natural Science Foundation of China (Nos. 30830100 and 30972924); the Scientific Research Foundation for the Returned Overseas Chinese Scholars State Education Ministry (No. 20101174-4-2)
  • 相关项目:重症急性胰腺炎坏死与凋亡分子XIAP,HSPA5,GSK3B,RIPK1的个体差异性
中文摘要:

在这份报纸客观,我们在尖锐胰腺炎(AP ) 在浆液 cytokines 上调查了繁体中文药 Chaiqin Chengqi 煎(CQCQD ) 的效果病人。

英文摘要:

Objective:In this paper,we investigated the effect of the traditional Chinese medicine Chaiqin Chengqi Decoction(CQCQD) on serum cytokines in acute pancreatitis(AP) patients.Methods:Peripheral blood samples from 107 AP patients were collected within the first 48 h of AP onset and on the 10th day of CQCQD treatment.Control samples were collected from 20 healthy individuals.Serum proinflammatory cytokines tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6),and anti-inflammatory cytokines IL-10 and IL-1β receptor antagonist(IL-1ra) were examined using the Luminex 100 system.Results:Within the first 48 h of AP onset,IL-6 and IL-1ra levels in severe AP(SAP) patients were significantly higher than those in mild AP(MAP) patients,but IL-10 levels in SAP patients were significantly lower than those in MAP patients.Proinflammatory cytokine IL-6 was significantly decreased after CQCQD treatment(P0.05),especially in SAP patients(n=25 of 36,P0.05).The hospitalization time of SAP patients was shortened significantly when serum IL-6 decreased after CQCQD treatment(P0.05).Conclusions:CQCQD decreased proinflammatory cytokine IL-6 levels in AP patients.

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期刊信息
  • 《中华实验外科杂志》
  • 北大核心期刊(2011版)
  • 主管单位:中国科学技术协会
  • 主办单位:中华医学会
  • 主编:
  • 地址:武汉市武昌区东湖路165号
  • 邮编:430064
  • 邮箱:cjes@cma.org.cn
  • 电话:027-87893475
  • 国际标准刊号:ISSN:1001-9030
  • 国内统一刊号:ISSN:42-1213/R
  • 邮发代号:38-85
  • 获奖情况:
  • 国内外数据库收录:
  • 美国化学文摘(网络版),日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊(2004版),中国北大核心期刊(2008版),中国北大核心期刊(2011版),中国北大核心期刊(2014版),中国北大核心期刊(2000版)
  • 被引量:34996