中文摘要：

多种病因能诱发ICH,如高血压、阿兹海默病、血管畸形和凝血病。ICH后继发性血脑屏障损伤机制研究分别在分子及细胞信号领域上已取得了长足进展,而血液成分中的凝血酶、血红蛋白、铁和继发性炎症反应在ICH诱导的继发性血脑屏障功能紊乱中都发挥了极其重要的作用。所以如何深入理解ICH后继发性血脑屏障功能紊乱的内在机理,对于我们进一步研究脑出血性脑卒中发病机制来说尤为关键。

英文摘要：

This paper summarized the main research progress which was relevant to the potential mechanisms of secondary blood-brain barrier（BBB） dysfunction in adults＇ intracerebral hemorrhage（ICH）. ICH correlated with many causes, illustrating with examples, cerebral vascular malformations, coagulopathies, high blood pressure and Alzheimer＇s disease. Remarkable achievement of the cell and molecular signal level has been obtained on the etiologies of BBB dysfunction after ICH.Hemoglobin, thrombin, iron of blood compositions and the inflammatory reaction to them have a big impact on BBB dysfunction after ICH. Knowing the mechanisms underlying the secondary BBB dysfunction after ICH is significant for studying the pathogenesis of cerebral hemorrhagic stroke.