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中文摘要：
用耗散粒子动力学（DPD）方法研究了稳定剂在负载布洛芬的固体脂质微颗粒（solid lipid microparticles，SLM）表面的分布状况。模拟结果表明：以卵磷脂为稳定剂，当布洛芬的摩尔分数为1％和2％时，卵磷脂较好地包覆在颗粒的表面；而当布洛芬的摩尔分数增大到3％和5％时，卵磷脂不能覆盖在布洛芬分子密集的部位。以poloxamer 407和PVA为稳定剂，随着布洛芬摩尔分数由1％增大到5％，稳定剂都能很好地包覆在颗粒的表面。实验现象较好地吻合了模拟结果。采用DPD模拟方法，可以加深了解多相复杂载药体系的微观结构并对实验现象进行分析，为SLM稳定剂的筛选提供理论指导。
英文摘要：
Dissipative particle dynamics （DPD） simulation was used to model the distribution of stabilizers （lecithin, poroxamer and PVA） on the surface of ibuprofen-loaded solid lipid microparticles （SLM） . It was shown from DPD simulation results that lecithin totally enwrapped the surface of SLM when the molar fraction of ibuprofen was 1% and 2 %. However, when the molar fraction of ibuprofen was increased to 3 and 5 %, lecithin could not cover the place with a higher concentration of ibuprofen molecules. Poloxamer 407 and PVA totally enwrapped the surface of SLM when the molar fraction of ibuprofen was increased from 1% to 5 %. The experimental results could be interpreted with the simulation results. DPD simulation provides an insight into the microstructure of a drug carrier and helps to analyze the experimental results, which is helpful in stabilizer selection for SLM.
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