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铅对神经系统学习记忆功能的损伤及药物的修复机制
  • ISSN号：0253-2778
  • 期刊名称：《中国科学技术大学学报》
  • 时间：0
  • 分类：Q593.2[生物学—生物化学]
  • 作者机构：[1]中国科学技术大学生命科学学院神经毒理学实验室,安徽合肥230027
  • 相关基金：国家重点基础研究发展（973）计划（2002CB512907）,国家自然科学基金重点项目（39630270,30630057）,国家自然科学基金（30170809,3000039,30300288）,中国科学院知识创新工程（KZCX2-410,ZCX3-SW-437）,教育部博士学科点专项科研基金（1999035811,20020358053）和中国科学技术大学基金（KB0811）资助. 致谢本实验室完成的各项研究成果,是所有参加本实验室工作的教员,博士后,博士生,硕士生和本科生的贡献,在此一并向他们表示感谢.
作者： 阮迪云[1]
关键词： 铅, 学习记忆, 突触可塑性, 通道和受体, 药物, 修复机制, lead, learning and memory, synaptic plasticity, channels and receptors, pharmacals, repair mechanism
中文摘要：

概述了中国科学技术大学神经毒理学实验室在铅对神经系统学习记忆功能的损伤及药物的修复机制方面的研究进展,主要包括：①铅对海马突触可塑性的影响;②铅影响离子通道的作用机制;③铅对NMDA受体、非NMDA受体及其通道特性的损伤;④铅与神经递质的相互作用;⑤铅影响基因对学习记忆的调控;⑥牛磺酸,神经节苷脂,抗氧化剂等药物对铅引起的学习记忆损伤的修复机制.

英文摘要：

The advances made in lead-induced impairment of learning and memory in the nervous system and mechanisms of pharmacals repair in Neurotoxicolog Lab in University of Science and Technology of China were described. They include：①the effect of lead on synaptic plasticity in hippocampus; ②the mechanism of effect of lead on ion channels; ③lead-induced impairment of NMDA receptor, non NMDA receptors and receptor channels; ④the interaction between lead and neurotransmitters; ⑤the effect of lead on gene regulation; ⑥the repair mechanism of pharmacals （Taurine, Ganglioside, antioxidants, etc. ） on lead-induced impairment.

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期刊信息
  • 《中国科学技术大学学报》
  • 北大核心期刊（2011版）
  • 主管单位:中国科学院
  • 主办单位:中国科学技术大学
  • 主编：何多慧
  • 地址：安徽省合肥市金寨路96号
  • 邮编：230026
  • 邮箱：JUST@USTC.EDU.CN
  • 电话：0551-63601961 63607694
  • 国际标准刊号：ISSN：0253-2778
  • 国内统一刊号：ISSN：34-1054/N
  • 邮发代号:26-31
  • 获奖情况:
  • 1999年，全国优秀高等学校自然科学学报及教育部优...,2001年，安徽省1999-2001年度优秀科技期刊一等奖,2002年，第三届华东地区优秀期刊奖
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  • 被引量:8237