目的 观察针刺对短暂性脑缺血发作(TIA)的GMP-140、TXB2、PGI2的影响及临床疗效。方法 将60例TIA患者随机分为针刺组和药物组(阿司匹林)。于治疗前后检测患者GMP-140、TXB2、PGI2并比较疗效。结果 治疗前两组血浆GMP-140、TXB2、PGI2含量比较差异无统计学意义(P>0.05);治疗后两组血浆PGI2均有升高(P<0.05),GMP-140、TXB2均有下降(P<0.05,P<0.01);两组治疗后血浆PGI2、GMP-140和TXB2含量比较差异均有统计学意义(P<0.05)。针刺组总有效率为96.7%,药物组为73.3%,两组比较差异有统计学意义(P<0.05)。结论 针刺和阿司匹林对TIA的GMP-140、TXB2、PGI2都有较大的影响,但针刺组的变化及临床疗效较药物组显著。
Objective To observe the effect of acupuncture on GMP-140, TXB2, and PGI2 in Transient Ischemic Attack (TIA) and its therapeutic effect. Method Sixty TIA patients were randomized into an acupuncture group and a medication group (Aspirin) GMP-140, TXB2, and PGI2 contents were determined before and after treatment, and therapeutic effects were compared. Result Before treatment, there were no significant differences between the two groups in comparing plasma GMP-140, TXB2, and PGI2 contents (P〉0.05); after treatment, PGI2 increased markedly (P〈0.05) and GMP-140 and TXB2 decreased markedly (P〈0.05,P〈 0.01) in both groups; after treatment, there were significant differences between the two groups in comparing plasma GMP-140, TXB2, and PGI2 contents (P〈0.05). The total effective rate was 96.7% in the acupuncture group versus 73.3% in the medication group, and the difference was statistically significant (P〈0.05). Conclusion Acupuncture and Aspirin both have significant effects on GMP-140, TXB2, and PGI2 contents in TIA, but the changes in the acupuncture group and its therapeutic effect are more significant than those in the medication group.