在现在的研究,二中国恒河猴与 SIVmac239 的 5000 TCID50 静脉内地被接种。在 CD4 的数字的变化[+] 在外部血的 T,血浆病毒的负担,专业版病毒的脱氧核糖核酸;对病毒的体液的抗体周期性地在 121 天期间被监视。在感染的早阶段,专业版病毒的脱氧核糖核酸在 PBMC 被检测了,;传染 SIVmac239 病毒从 PBMC 被孤立。在一样的时期, CD4 的数字[+] T 显著地被减少,;在 121 天的感染期期间在底层维持了。血浆病毒的负担在星期 2 点到达了山峰接种以后;随后在一个稳恒状态保留了。而且,对病毒蛋白的抗体从血浆被检测。所有结果证明二中国恒河猴成功地感染了 SIVmac239。这个动物模型能进一步被申请爱滋病研究。
In the present research, two Chinese rhesus monkeys were inoculated intravenously with 5000 TCID50 of SIVmac239. The changes in the numbers of CD4^+T lymphocyte in peripheral blood, plasma viral loads, proviral DNA and humoral antibodies against virus were periodically monitored during 121 days. At the early stage of infection, proviral DNA had been detected in PBMCs, and infectious SIVmac239 virus had been isolated from PBMCs. At the same period, the numbers of CD4^+ T lymphocytes were significantly decreased, and maintained at low level during the 121-day period of infection. Plasma viral loads reached the peak at week 2 post-inoculation and kept at a steady state subsequently. Moreover, antibodies against viral proteins were detected from plasma. All the results showed that the two Chinese rhesus monkeys had been infected with SIVmac239 successfully. This animal model can be applied for further AIDS researches.