中文摘要：

目的：通过以高脂饲料模拟过食肥甘酿生痰湿,观察其对低剂量链脲佐菌素塑造2型糖尿病动物模型的成模情况的影响,为用祛痰除湿法治疗2型糖尿病提供借鉴。方法：12只正常雄性SD大鼠,按体重随机分成痰湿组和对照组。其中痰湿组喂食高脂饲料,对照组喂食普通饲料。4周后,早晨8：00至下午20：00禁食不禁水12 h,称量大鼠体重,测空腹血糖。将链脲佐菌素按30 mg/kg的剂量腹腔注射,连续3 d。于最后1日注射后48 h及72 h测空腹血糖。以空腹血糖≥11.1 mmol/L为该模型糖尿病诊断切点。结果：痰湿组成模率高于对照组。结论：内生痰湿是2型糖尿病发病的重要因素,其能够稳定提高2型糖尿病大鼠造模成模率。适当祛痰除湿,能有效防治2型糖尿病。

英文摘要：

Objective： Through simulation with high fat feed overeating fat to produce endogenous phlegm- dampness,to observe high fat feed influence on shaping type 2 diabetes mellitus animal model with low dose of streptozotocin（ STZ） and to provide an reference for treatment of type 2 diabetes mellitus by removing phlegm and dampness. Methods： Twelve normal male SD rats,according to the weight,were randomly divided into the phlegm- dampness group and the control group. The phlegm- dampness group was fed high fat while the control group ordinary feed. After 4 weeks,from 8： 00 to 20： 00 all rats were fast,but the water was not,we weighed the rats weight and measured fasting blood glucose（ FBG）. All rats did intraperitoneal injection with streptozotocin by 30 mg / kg for 3 consecutive days. In the last one day after injection of 48 h and 72 h measured fasting blood glucose.FBG≥ 11. 1 mmol / L was to be the diagnosis of tangent point,model of type 2 diabetes mellitus. Results： The model rate of the phlegm- dampness group was higher than that of the control group. Conclusion： Endogenous phlegm- dampness is an important factor in the pathogenesis of type 2 diabetes mellitus,which can stablely increase the model rate of type 2 diabetic millitus rats.Appropriately removing phlegm and dampness is the effective prevention and treatment of type 2 diabetes mellitus.