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中文摘要：
目的为了探求慢性乙型肝炎患者血清中环氧化酶-2（COX-2）的表达情况及其临床意义。方法选择正常对照组10例，慢性乙型肝炎轻、中、重度各10例，肝硬化病人10例作为本实验的研究对象，应用ELISA法进行血清样本COX-2测定，并结合病情轻重进行综合分析。结果慢性乙型肝炎组和肝硬化组血清中COX-2阳性率明显高于对照组（P〈0．01），血清COX-2含量显著高于对照组（P〈0．01）。慢性乙型肝炎各组病人组血清中COX-2含量存在显著的差异（P〈0．05）。结论COX-2在慢性乙型肝炎患者血清中呈现出高表达，并且在其发病过程中起着重要的作用。
英文摘要：
Objective To study the significance of serum cyclooxygenase-2 （COX-2） expression in the patients chronic hepatitis B. Methods The serum COX-2 protein was determined in 30 chronic hepatitis B, 10 hepatic cirrhosis, 10 control cases by ELISA and analyzed combined with clinical data. Results The expression of serum COX-2 in chronic hepatitis B was obviously higher than the controls （P〈0.01）, also increased with hepatic inflammation getting worse （P〈0.05）. Conclusions The result of the present study suggests that COX-2 is involved in hepatic inflammation, and maybe play a rote in chronic hepatitis B, and hepatic fibrosis, cirrhosis.
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