中文摘要：

自噬（autophagy）是真核细胞通过溶酶体对其自身结构进行降解的一个生物学过程,其在细胞的生存、生长、分化以及维持内环境稳定等方面发挥着重要的作用。在肿瘤的发生和发展过程中,自噬的调控机制比较复杂,且具有两面性。在肿瘤发生的早期,自噬可以通过清除受损细胞器、促进蛋白分解代谢而发挥抑制肿瘤的作用。然而,在肿瘤进展中,在缺氧或营养受限的状态下,肿瘤细胞可通过自噬的作用降解、循环再利用细胞内物质,促进自身存活。前列腺癌是男性生殖系统中最常见的恶性肿瘤。近年来的研究表明,前列腺癌的发生和发展与自噬密切相关。因此,本文就自噬在前列腺癌中的调控机制进行综述,以期为前列腺癌的治疗提供一些新的线索和途径。

英文摘要：

Autophagy is a metabolic process whereby intracellular substance is degraded in lysosomes of eukaryotic cells, which plays an important role in cell survival, growth, differentiation and maintenance of cellular homeostasis. The regulatory mechanism by which autophagy contributes to tumorigenesis is complex and also exhibits the effects of a double-blade sword. At the earlier stage of the neoplastic process, autophagy can inhibit the formation of tumor by preventing the accumulation of damaged organelles and accelerating the protein degradation process. However, in the process of tumor development, autophagy can help tumor cells survive under the conditions of hypoxia and nutrient deprivation by degrading and recycling intracellular substances. Prostate cancer is the most common malignant tumor in male genital system. Rrecent studies show that autophagy is closely related to tumorigenesis, and therefore the molecular mechanism of autophagy has been the focus of research. This review focuses on the regulatory mechanism of autophagy in prostate cancer, hoping to provide a theoretical basis of autophagy for the treatment of prostate cancer.