中文摘要：

目的研究促排卵晚期白细胞与基础白细胞的比值(LLC/BLC)和中性粒细胞与淋巴细胞的比值(N/L)对卵巢过度刺激综合征(OHSS)发生及严重程度的预测效果。方法将2015年5至8月在本中心行体外受精-胚胎移植(IVF-ET)助孕促排卵并发生中-重度OHSS的69例患者作为OHSS组,按匹配标准选择同期在本中心行IVF促排卵且未发生OHSS的70例患者作为对照组,进行回顾性分析,分析基础N/L、促排卵晚期N/L、LLC/BLC与OHSS发生发展的关系。结果 OHSS组及对照组均能发现促排卵晚期N/L(OHSS组2.47;对照组2.39)较基础N/L(OHSS组1.70;对照组1.94)升高,且差异具有统计学意义(P<0.001)。将OHSS组与对照组相比较,基础N/L(1.70与1.94)和促排卵晚期N/L(2.47与2.39)在两组间的差异均无统计学意义(P>0.1)。而OHSS组的LLC/BLC(1.51)比对照组(1.37)高,且差异具有统计学意义(P=0.006)。对照组(1.37)、中度OHSS组(1.48)、重度OHSS组(1.56)的LLC/BLC逐渐升高,且差异具有统计学意义(P=0.008)。结论促排卵周期中N/L的显著升高提示存在炎症发生的过程。LLC/BLC可作为OHSS发生及严重程度的预测因子。在IVF促排卵过程中,LLC/BLC越高,发生中-重度OHSS的可能性越大,OHSS的程度也越重。

英文摘要：

ObjectiveTo investigate the efficiency of controlled ovarian hyperstimulation late period leukocyte count/basic leukocyte count (LLC/BLC) and neutrophil/lymphocyte (N/L) predicting the occurrence and development of ovarian hyperstimulation syndrome (OHSS).MethodsClinical data of 139 patients who underwent IVF in our center from May 2015 to August 2015 were analyzed retrospectively. The study group consisted of 69 patients who developed moderate-severe OHSS after ovarian stimulation and 70 patients who were not included in control group by matched criteria. The relationship between basic N/L, controlled ovarian hyperstimulation late period N/L, LLC/BLC and the occurrence and development of OHSS was mainly analyzed.ResultsControlled ovarian hyperstimulation late period N/L (OHSS group 2.47; control group 2.39) was significantly elevated compared to baseline (OHSS group 1.70; control group 1.94) in both OHSS group and control group (P<0.001). There was no significant differences in terms of basic N/L (1.70vs.1.94) and controlled ovarian hyperstimulation late period N/L (2.47vs.2.39) between OHSS group and control group (P>0.1). LLC/BLC was significantly elevated in OHSS group (1.51) compared with control group (1.37) (P=0.006). LLC/BLC was gradually elevated from control group (1.37) to moderate OHSS group (1.48) to severe OHSS group (1.56), and the elevation was significant (P=0.008).ConclusionsThe significant elevation of N/L during controlled ovarian hyperstimulation suggests inflammation is involved. LLC/BLC can be used to predict the occurrence and development of OHSS. A higher LLC/BLC in an IVF cycle suggests a greater likelihood of occurrence of moderate-severe OHSS, and the severity of OHSS increases as the degree of LW/BW elevation increases.