中文摘要：

目的探讨高血压伴心房颤动（房颤）患者的血浆血管紧张素Ⅱ（AngⅡ）水平及其对应用肾素-血管紧张素系统（RAS）阻滞剂的指导意义。方法选取2010年1月—2011年12月在上海交通大学附属第一人民医院住院治疗的单纯高血压患者114例,为高血压组;另选取同期在本院住院治疗的高血压伴房颤患者107例,为高血压伴房颤组。采用放射免疫法检测两组患者的血浆AngⅡ水平,采用多因素Logistic回归分析探讨其对高血压伴房颤的影响。结果两组患者性别、年龄、收缩压、舒张压、左心房内径、左心室收缩末期内径、左心室舒张末期内径比较,差异无统计学意义（P〉0.05）;高血压伴房颤组患者血浆AngⅡ水平高于高血压组,差异有统计学意义（P〈0.05）。高血压伴房颤组（95.3%,102/107）血浆AngⅡ水平升高发生率高于高血压组（8.8%,10/114）,差异有统计学意义（P〈0.05）。多因素Logistic回归分析结果显示,血浆AngⅡ水平是高血压伴房颤的影响因素（P〈0.05）。结论高血压伴房颤患者的血浆AngⅡ水平明显高于单纯高血压患者,血浆AngⅡ水平是高血压伴房颤的影响因素,可以作为高血压伴房颤患者治疗中应用血管紧张素转换酶抑制剂（ACEI）/血管紧张素Ⅱ受体拮抗剂（ARB）类药物的标志物。

英文摘要：

Objective The purpose of this study was to investigate the predictive value of plasma angiotensin Ⅱ（AngⅡ） levels for the medication of renin-angiotensin system（RAS） blockers,angiotensin-converting enzyme inhibitor（ACEI）/angiotensin receptor blockers（ARB） in hypertensive patients with atrial fibrillation（AF）.Methods The study included 114 hypertensive patients（hypertension group） and 107 hypertensive patients with AF（hypertension with AF group）.They were selected from the patients who were hospitalized in the First People＇ s Hospital Affiliated with Shanghai Jiao Tong University from January 2010 to December 2011.Their plasma Ang Ⅱ levels were measured by radioimmunoassay.Multivariate Logistic regression analysis was performed to investigate the effect of plasma Ang Ⅱ levels on hypertension with AF.Results There were no significant differences between the two groups in sex,age,systolic blood pressure,diastolic blood pressure,left atrial diameter,left ventricular end-systolic diameter and left ventricular end-diastolic diameter（P〈0.05）.Hypertension with AF group had significantly higher levels of plasma Ang Ⅱ（P〈0.05）.Patients in the hypertension with AF group were more likely to have elevated plasma Ang Ⅱ levels than those in the hypertension group [95.3%（102/107） vs.8.8%（10/114）,P〈0.05].Multivariate Logistic regression analysis showed that plasma Ang Ⅱ levels was significantly associated with hypertension with AF（P〈0.05）.Conclusion Hypertensive patients with AF have significantly higher plasma Ang Ⅱ levels than those without.Plasma AngⅡ levels is an associated factor for hypertension with AF,which may be used as a marker for the medication of ACEI/ARB in these patients.