中文摘要：

奈必洛尔是一种新型的第三代肾上腺素β受体阻滞药，对β1受体具有高选择性，可通过内皮L-精氨酸／一氧化氮途径扩张血管，清除自由基，改善内皮功能，还具有不干扰糖脂代谢、抗血小板聚集等优点。本文综述了奈必洛尔的结构特点、药动学、作用机制和临床研究进展。

英文摘要：

Nebivolol is a new type of third-generation 13-adrenergic blocker with high setecUvlty for β1- adrenergic receptors, which also causes vasodilation by interaction with the endothelial L- arginine/nitric oxide pathway, scavenges reactive oxygen species and improves endothelial function. No significant changes on glucose and lipid metabolism were noted with nebivolol. Furthermore, nebivolol possess the greatest inhibition effect on platelet aggregation. This paper reviews the pharmacology structure, the pharmacokinetics, mechanism of action and the progress of clinical research of nebivolol.