中文摘要：

在单个分子的水平在表面上吸附的 biomolecules 的符合构造的精确控制是重要的。然而，因为复杂结构和 biomolecules 的符合构造差异，它仍然是巨大的挑战。此处，限制 nanopore 的识别策略被建议通过 functionalized 的精确设计在房间温度操作单个 valinomycin 分子的吸附结合的 macrocycle (CPN8 ) 有互补体系结构和有约束力的地点的超分子的 nanopores。我们表明 CPN8 与因为在 valinomycin 的 isopropyl 组和 CPN8 的氨基的组之间的强壮的 synergistic 相互作用，有选择地与互补建筑学认出 valinomycin 比比较喜欢，与 valinomycinhighly 面向的 pyrolytic 石墨(HOPG ) 相互作用。我们在单个分子的水平的观点将提供珍贵卓见为非结合的分子的符合构造选择的识别改进超分子的 nanopores 的设计。

英文摘要：

The precise control of the conformations of biomolecules adsorbed on a surface at the single-molecule level is significant. However, it remains a huge challenge because of the complex structure and conformation diversity of biomolecules. Herein, a ＂nanopore-confined recognition＂ strategy is proposed to manipulate the adsorption of individual valinomycin molecules at room temperature through precise design of functionalized conjugated macrocycle （CPN8） supramolecular nanopores with complementary architectures and binding sites. We revealed that CPN8 prefers to selectively recognizing valinomycin with complementary architecture because of the strong synergistic interactions between the isopropyl groups of valinomycin and the amino groups of CPN8, with valinomycin- highly oriented pyrolytic graphite （HOPG） interactions. Our perspectives at the single-molecule level will provide valuable insights to improve the design of supramolecular nanopores for conformation-selective recognition of non-conjugated molecules.