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核膜血影重复蛋白研究进展
  • ISSN号：1000-3282
  • 期刊名称：生物化学与生物物理进展
  • 时间：2014
  • 页码：337-344
  • 期号：04
  • 便笺：11-2161/Q
  • 分类：Q71[生物学—分子生物学] R34[医药卫生—基础医学]
  • 作者地址：心律失常教育部重点实验室(同济大学);同济大学医学遗传研究所;同济大学医学院再生医学系;同济大学医学院病理与生理学系;同济大学附属东方医院心脏内科;
  • 作者机构：[1]心律失常教育部重点实验室(同济大学),上海200092, [2]同济大学医学遗传研究所,上海200092, [3]同济大学医学院再生医学系,上海200092, [4]同济大学医学院病理与生理学系,上海200092, [5]同济大学附属东方医院心脏内科,上海200120
  • 相关基金：国家重点基础研究发展计划（973）（2013CB5311OO）,国家自然科学基金委员会创新研究群体项目（81221001）,国家自然科学基金委员会重大国际（地区）合作项H（81120108004）,同济大学医学院扬帆计划项目（2012YF05）资助.
作者： 赵春霞;崔映宇;陈义汉;
关键词： 核膜血影重复蛋白, 细胞骨架, 细胞核, 核纤层蛋白病, Nesprins, nucleus, cytoskeleton, Laminopathy
中文摘要：

核膜血影重复蛋白（Nesprins）连接细胞核与多种细胞骨架和（/或）细胞器，在细胞核与细胞骨架定位、质一核间物质运输和动力传导、核膜构建、细胞迁移、锚定和极性建立等过程中发挥重要作用．本文综述核膜血影重复蛋白的发现、编码基因、结构、功能以及与相关疾病的关系研究现状，并展望潜在的未来研究动向．

英文摘要：

The nuclear envelope spectfin repeat proteins （Nesprins）, connecting me nuct~ua w ~ cytoskeleton and/or organelles, play important roles in nucleus and cytoskeleton positioning, power and material transporting between nucleus and cytoplasm, nuclear envelope constructing, cell migrating, anchoring and polarizing. Their discoveries, encoding genes, structural characters, functions and related diseases were summarized in this review, and their further research pulses are also prospected meanwhile.

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期刊信息
  • 《生物化学与生物物理进展》
  • 中国科技核心期刊
  • 主管单位:中国科学院
  • 主办单位:中国科学院生物物理研究所 中国生物物理学会
  • 主编：王大成
  • 地址：北京市朝阳区大屯路15号
  • 邮编：100101
  • 邮箱：prog@sun5.ibp.ac.cn
  • 电话：010-64888459
  • 国际标准刊号：ISSN：1000-3282
  • 国内统一刊号：ISSN：11-2161/Q
  • 邮发代号:2-816
  • 获奖情况:
  • 1999年中国期刊奖提名奖,2000年中国科学院优秀期刊特别奖
  • 国内外数据库收录:
  • 美国化学文摘（网络版）,荷兰文摘与引文数据库,美国剑桥科学文摘,美国科学引文索引（扩展库）,美国生物科学数据库,日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊（2004版）,中国北大核心期刊（2008版）,中国北大核心期刊（2011版）,中国北大核心期刊（2014版）,中国北大核心期刊（2000版）
  • 被引量:18821