中文摘要：

体内雌激素水平下降是引起骨质疏松的重要因素，用雌激素治疗绝经后妇女的骨质疏松症（osteoporosis，OP）会引发乳腺癌，因而人们使用选择性雌激素受体调节剂（selective estrogen receptor modulator，SERMs）来治疗绝经后妇女OP。SERMs可选择的作用于雌激素受体（estrogen receptor，ER），抑制骨吸收、破骨细胞形成而阻止骨质流失。SERMs是目前比较理想的治疗绝经后妇女OP的药物。本文就SERMs的作用机制及其治疗OP效果进行综述，并探讨SERMs治疗绝经后OP的前景和意义。

英文摘要：

The reduction of estrogen is the main cause that leads to osteoporosis（OP）. Selective estrogen receptor modulators （SERMs） have been developed and applied for the treatment of postmenopausal OP because breast cancer is triggered while using estrogen to cure OP. SERMs selectively act on the estrogen receptor that could inhibit the absorbability of bone and the formation of osteoclast, this manner may prevent the loss of bone mineral density. Presently, it is considered that SERMs were the ideal drugs for curing postmenopausal OP. In the paper, the functional mechanism of SERMs and their effects on curing OP were summarized, the scientific significance and perspective for application of SERMs on the therapy of postmenopausal OP were discussed.