中文摘要：

客观 p53 是肿瘤 suppressor 基因并且涉及卵巢的癌症的病原学。调查在 72 多型性和卵巢的癌症风险显示出冲突结果的 p53 codon 之间的协会的研究。我们从合格研究执行了这元分析评估这种声称的关系。这元分析从 9 盒子控制研究被执行的方法，包括 825 个卵巢的案例和 1073 控制。他修理了的 T 和随机的效果模型被用来为这多型性的各种各样的对比估计机会比率(ORs ) 。结果联合结果基于所有研究证明显著地减少的风险与变体职业人员 / 职业人员遗传型被联系，与 Arg/Pro+Arg/Arg 遗传型相比(或， 0.70；95%CI， 0.510.95 ) 。当成层时由种族的研究，我们发现有变体遗传型职业人员 / 职业人员的个人与 Arg/Arg 遗传型相比有卵巢的癌症的显著地减少的风险(或， 0.43；95%CI， 0.200.89 ) 并且 Arg/Pro+Arg/Arg 遗传型(或， 0.61；95%CI， 0.370.99 ) 在非洲人之中。结论这元分析建议 72 多型性可以贡献的 p53 codon 基因危险性到卵巢的癌症。更多的研究应该基于更大的样品尺寸被执行证实调查结果。

英文摘要：

Objective： p53 is a tumor suppressor gene and is involved in the etiology of ovarian cancer. Studies investigating the associations between the p53 codon 72 polymorphism and ovarian cancer risk showed conflicting results. We performed this meta-analysis from eligible studies to evaluate this purported relationship. Methods： This meta-analysis was performed from 9 case-control studies, including 825 ovarian cases and 1073 controls. The fixed and random effect models were used to estimate the odds ratios（ORs） for various contrasts of this polymorphism. Results： The combined results based on all studies showed that a significantly decreased risk was associated with the variant Pro/Pro genotype, compared with Arg/Pro＋Arg/Arg genotypes（OR, 0.70; 95%CI, 0.51-0.95）. When stratifying the studies by ethnicity, we found that individuals with the variant genotype Pro/pro had a significantly decreased risk of ovarian cancer compared with Arg/Arg genotype（OR, 0.43; 95%CI, 0.20-0.89） and Arg/Pro＋Arg/Arg genotypes（OR, 0.61; 95%CI, 0.37-0.99） among Africans. Conclusion： This meta-analysis suggests that the p53 codon 72 polymorphism may contribute to genetic susceptibility to ovarian cancer. More studies based on larger sample size should be performed to confirm the findings.