中文摘要：

通过阳极氧化技术,在钛表面制备一层管径为100nm左右的氧化钛纳米管.选取小牛血清白蛋白（BSA）和纤维连接蛋白（FN）两种蛋白质进行蛋白吸附实验,并在仿生条件下进行蛋白质的体外释放.对吸附了蛋白的纳米管试样表面进行红外和荧光定性分析,同时采用考马斯亮蓝法对纳米管表面的蛋白吸附进行定量检测,实验发现纳米管试样更有利于蛋白质的吸附,且FN在试样表面吸附时的吸附率大于BSA.氧化钛纳米管的蛋白释放分为突释和缓释两个阶段,其释放机制符合Fickian扩散.

英文摘要：

The titanium dioxide（TiO2） nanotube arrays with 100 nm diameters on titanium were fabricated by anodic oxidation.The adsorption behaviors of bovine serum albumin（BSA） and fibronectin（FN） onto the nanotube arrays were investigated,and then the protein releases were examined in vitro.Fourier transform infrared spectroscope and Fluorescence microscope were used to qualitative analysis for TiO2 nanotube arrays surfaces after protein adsorption.Adsorbance of protein was detected with the method of Coomassie brilliant blue G-250.The results showed that TiO2 nanotube arrays could obviously improve the adsorption,and the adsorption percentage of FN on samples was larger than that of BSA.The release experiment results suggested that the release behaviors of BSA and FN on the nanotube arrays involved the bust release and the gradual release,and the release mechanism was consistent with Fickian diffusion.