中文摘要：

心房颤动是最常见的持续性心律失常并增加缺血性卒中风险，长期口服抗凝药物治疗是预防房颤患者卒中较为常规的治疗手段，但许多房颤患者存在抗凝治疗的绝对或相对禁忌证。左心耳封堵术（left atrial appendage closure，LAAC）为栓塞高危伴出血高危或口服抗凝药（oral anticoagulation，OAC）禁忌者提供了另外一种选择。预防LAAC术后封堵器血栓形成以及减少出血事件对于成功的LAAC术至关重要。因此选择合适的术后抗栓策略尤为关键。

英文摘要：

Atrial fibrillation （AF） is the most common sustained arrhythmia, which increases the risk of ischemic stroke. Long-term oral antithrombotic therapy has been widespread used as a major strategy in patients at high risk of ischemic stroke in association with atrial fibrillation, but many patients cannot achieve anticoagulation targets due to contraindications to its application or bleeding. Left atrial appendage closure （LAAC） has emerged as an alternative treatment for patients with atrial fibrillation who are at high risk of ischemic stroke and have contraindications for anticoagulation. It is important to prevent on-device thrombus formation without increasing the risk for bleeding complications after successful interventional left atrial appendage closure. Therefore, choosing the optimal antithrombotic therapy is very important after LAAC.