中文摘要：

Vinculin是一种细胞骨架蛋白兼粘着斑组成蛋白,主要分布于细胞-细胞连接处及细胞-细胞外基质（extracellular matrix,ECM）粘着斑部位.Vinculin通过与多种粘着斑蛋白、细胞骨架蛋白及细胞骨架F-肌动蛋白相结合并相互作用,参与细胞的力-化学信号转导,在细胞粘附、伸展、运动、增殖、存活等过程中起重要作用.本文结合本课题组研究工作,在介绍vinculin分子结构的基础上,对其在细胞力-化学信号转导中的作用做一综述.

英文摘要：

Vinculin is a focal adhesion and cytoskeletal protein that distributed mainly at cell-cell junctions and cell-extracellular matrix（ECM） adhesions.Vinculin is involved in the mechano-chemical signal transmission of cells by binding to a variety of focal adhesion or cytoskeletal proteins,and plays important roles in cell adhesion,extension,motion,proliferation and survival.This review focuses on the molecular structure of vinculin and its role in the mechanotransduction.