以苄胺和苯乙炔为底物,以水溶性(NH_2CH_2COOH)_2PdCl_2为催化剂,K_2CO_3和AgNO_3为助催化剂,在DMF中一步合成2,3,6-三苯基吡啶杂环化合物,产物经~1H、~(13)C核磁共振谱进行了表征。考察了碱,反应温度、催化剂用量、反应时间等对催化反应的影响,确定了最佳的反应条件。在最佳的反应条件下,目标化合物的收率为57%。
The compound, 2, 3, 6 -triphenylpyridine, was synthesized by catalytic heterocyclization from phe- nylmethanamine and ethynylbenzene using hydrophilie (NH2CH2COOH)2PdC12 as catalyst and K2CO3, AgNO3 as cocatalyst in DMF. The structure of the target complex was characterized by 1H NMR and^13C NMR. The optimal conditions of base, reaction temperature, catalyst loading and reaction time were investigated. The separate yield of the target compound was 57% under the optimal conditions.