中文摘要：

目的应用超声技术研究不同浓度FeCl3联合不同干预方法制备兔股动脉内混合性血栓的影响因素，达到为溶栓研究提供稳定、方便的血栓模型。方法30只新西兰大白兔总60条股动脉，分别根据FeCl3浓度、外敷法和内注射法和是否联合股动脉远端夹闭将动物分为3组，应用超声监测血栓形成情况，然后对血管行病理检查。结果外敷10％FeCl3联合股动脉夹闭形成闭塞性血栓优于其他浓度（P〈0．001），FeCl3外敷法形成血栓优于内注射法（P〈O．001），10％FeCl3外敷法联合远端夹闭形成血栓优于无夹闭的条件（P〈O．001）。结论股动脉10％FeCl3外敷联合夹闭是形成血小板为主的混合性血栓的最优方法。

英文摘要：

Objective To analyze the influence factor of different doses of ferric chloride combined with different intervention methods in inducing occlusive and platelet-rich thrombus thus affording a stable and convenient animal model for thrombolysis research. Methods A total of 30 rabbits and 60 arteries were divided into three groups by the following factors： doses of ferric chloride, methods of out-applying,inter-injection, to observe thrombus formation, monitoring thrombosis by ultrasound and pathological examination. Results Occlusive thrombus formed by external applying 10% ferric chloride outperformed other doses （P〈0. 001）, occlusive thrombus formed by external applying 10% ferric chloride outperformed inter-injection （P〈0. 001）, and occlusive thrombus formed by external applying 10% ferric chloride combined with the completely occlusive distal of femoral artery outperformed that without occlu- sion （P〈0. 001）. Conclusions Occlusive thrombus formed by external applying 10% ferric chloride combined with femoral artery occlusion is the key factor in successfully inducing the occlusive and platelet rich thrombus formation.