中文摘要：

成年干细胞的增长和区别必须紧被控制以便维持居民织物动态平衡。干细胞的机能障碍在许多人的疾病被含有，包括癌症。然而，干细胞增长和区别的规定充分没被理解。这里，我们证明象无菌一样 20 kinase，道，由在果蝇成年 midgut 调整河马小径的控制织物动态平衡。在祖先的道的弄空导致快速的肠的干细胞(ISC ) 增长和 midgut 动态平衡损失。同时，我们发现表明活动和 cytokine 生产的抄写(STAT ) 的 Janus kinase (JAK )/signal 变换器和使活跃之物显著地被增加，导致刺激 ISC 增长。而且，河马小径的表示下游地指向， Diap1 和矮鸡，戏剧性地在道击倒的肠被增加。一致地，我们证明 Yorkie (Yki ) 道下游地行动调整 ISC 增长。一起，我们的结果提供卓见进我们干细胞增长和织物动态平衡控制的机制的理解。

英文摘要：

The proliferation and differentiation of adult stem cells must be tightly controlled in order to maintain resident tissue homeostasis. Dysfunction of stem cells is implicated in many human diseases, including cancer. However, the regulation of stem cell proliferation and differentiation is not fully understood. Here we show that the sterile-like 20 kinase, Tao, controls tissue homeostasis by regulating the Hippo pathway in the Drosophila adult midgut. Depletion of Tao in the progenitors leads to rapid intestinal stem cell （ISC） proliferation and midgut homeostasis loss. Meanwhile, we find that the Janus kinase （JAK）/signal transducer and activator of transcription （STAT） signaling activity and cytokine production are significantly increased, resulting in stimulated ISC proliferation. Furthermore, expression of the Hippo pathway downstream targets, Diapl and bantam, is dramatically increased in Tao knockdown intestines. Consistently, we show that the Yorkie （Yki） acts downstream of Tao to regulate ISC proliferation. Together, our results provide insights into our understanding of the mechanisms of stem cell proliferation and tissue homeostasis control.