中文摘要：

目的：探讨经多孔材料处理的大黄蛰虫丸抗动脉血栓形成机制。方法：将大鼠分为正常组，模型组，多孔材料第1组1—5μm孔径，第2组孔径为5—10μm，第3组孔径为10—15μm，共5组，通过钛铝金属间化合物多孔材料分离筛选大黄蛰虫丸，用处理过的药物干预大鼠，收集血液、血栓模型等，分析血液中血小板计数、血浆血栓素B2（TXB-2）和6酮前列腺Flα（6-keto—PGFld）含量。结果：发现钛铝金属间化合物多孔材料能有效分离筛选大黄蛰虫丸，以孔径为1—5μm为最优。且大黄蜇虫丸能升高6-keto-PGFlOL，降低TXB-2，降低血小板含量，有良好的抗动脉血栓形成作用。结论：多孔材料处理过的药物具有良好地抗血栓形成作用。

英文摘要：

Objective： Research on the mechanism of antithrombotic of Dahuang Zhechong Wan Separated and purified by Ti-A1 intermetallic compound porous material （TAICPM）. Methods： Dahuang Zhechong Wan which were isolated and screened by TAICPM were used to oral rats. At the end of study, the blood and thrombus were collected. Results： TAICPM, especially the pore size of 1-5pro could screen Dahuang Zhechong Wan well. Dahuang Zhechong Wan could increase 6-keto-PGF1α, lower content of TXD2 and platelet. Conclution： Dahuang Zhechong Wan has a good effect on resistance arterial thrombosis.