中文摘要：

5-羟色胺（5-HT）介导的肺血管重构是肉鸡肺动脉高压综合征（PHs）形成的重要病理机制，而5-羟色胺转载体抑制剂已被证明能够抑制肉鸡肺血管重构，降低PHS的发病率，但其机理尚不十分清楚。为了从肺组织胶原蛋白沉积的角度探讨5-羟色胺转载体抑制剂抑制肉鸡肺血管重构的机理。本试验采用翅静脉注射纤维素颗粒的模型诱发肉鸡PHS，分别给诱病肉鸡灌服两种5-羟色胺转载体抑制剂，即氟西汀（uoxetine）和西酞普兰（citalopram）。使用分光光度法测量肉鸡肺组织胶原蛋白含量，采用ELlSA方法测量肺组织5-羟色胺浓度，观察各组肉鸡肺组织胶原蛋白含量和5-羟色胺浓度的差异。结果显示，发病组肉鸡肺组织5-羟色胺浓度和胶原蛋白含量高于正常对照组肉鸡，而氟西汀和西酞普兰均能降低PHS肉鸡肺组织胶原蛋白含量和5-羟色胺浓度，表明5-羟色胺转载体抑制剂能降低肺成纤维细胞合成胶原蛋白的能力，进而影响肺血管重构和PHS的发生。

英文摘要：

Pulmonary vascular remodeling mediated by serotonin plays a very important role in the pathogenesis of pulmonary hypertension syndrome （PHS） in broilers, and studies have confirmed that serotonin transporter inhibitor can decrease the risk of vascular remodeling and PHS. But the pathogenesis is still not clearly understood. In this study, we will discuss the effect of serotonin transporter inhibitors on the pathogenesis of vascular remodeling in terms of collagen deposition in lung tissues. PHS was induced by intravenous injection of cellulose particles through wing vein. Two kinds of serotonin transporter inhibitor named fluoxetine and citalopram were drenched to the PHS broilers separately. A UVspectrophotom etry was used to determine the lung collagen content, and an ELISA kit was used to investigate the serot0 nin levels of the lung tissues from broilers in different groups. After intravenous injection of cellulose par ticles, both 5HT levels and collagen content were increased in PHS broilers compared to the control group. Orally administration of fluoxetine and citalopram decreased the 5HT levels and collagen content in PHS broilers. This indicated that serotonin transporter inhibitor may decrease the collagen synthesis by lung fibroblasts and protect against the development of both vascular remodeling and PHS.