中文摘要：

瞄准：与肝炎 B 病毒相关的 acute-on-chronic 肝失败(HBV-ACLF ) 在病人调查幸存率和预示的因素。方法：在有从 2006 ～ 2009 承认的 HBV-ACLF 的就医的病人的临床的数据回顾地被分析。他们的一般条件和幸存被幸存分析和考克斯回归分析分析。结果：190 个病人的一个总数在这研究被包括。全面 1 年的幸存率是 57.6% 。没与抗病毒的药对待的病人有显著地更高的死亡[相对风险(RR )= 0.609， P = 0.014 ] 。在有 ACLF 的病人的死亡的最高的风险与 hepatorenal 症候群( HRS )被联系( RR = 2.084 ， P =0.026 )当另外的重要因素是电解质骚乱时( RR = 2.062 ， P = 0.010 )，并且肝的 encephalopathy (他)( RR = 1.879 ， P < 0.001 )。结论：抗病毒的治疗由改进他们的 1 年的幸存率与 HBV-ACLF 在病人的预后上有强壮的效果。HRS，电解质骚乱，并且他也影响耐心的幸存。

英文摘要：

AIM：To investigate the survival rates and prognostic factors in patients with hepatitis B virus-related acuteon-chronic liver failure（HBV-ACLF）.METHODS：Clinical data in hospitalized patients with HBV-ACLF admitted from 2006 to 2009 were retrospectively analyzed.Their general conditions and survival were analyzed by survival analysis and Cox regression analysis.RESULTS：A total of 190 patients were included in this study.The overall 1-year survival rate was 57.6%.Patients not treated with antiviral drugs had a significantly higher mortality[relative risk（RR）=0.609,P=0.014].The highest risk of death in patients with ACLF was associated with hepatorenal syndrome（HRS）（RR=2.084,P=0.026）,while other significant factors were electrolyte disturbances（RR=2.062,P=0.010）,and hepatic encephalopathy（HE）（RR=1.879,P0.001）.CONCLUSION：Antiviral therapy has a strong effect on the prognosis of the patients with HBV-ACLF by improving their 1-year survival rate.HRS,electrolyte disturbances,and HE also affect patient survival.