中文摘要：

以诺蒎酮为原料,合成了新型蒎烷基吡唑酰胺类衍生物,并对其生物活性进行了研究.诺蒎酮与芳香醛进行缩合反应,得到中间体3-芳亚甲基诺蒎酮2a～2g,2a～2g与水合肼经环化、脱氢芳构化反应,得到新型蒎烷基吡唑类化合物3a～3g;以N,N-二甲基甲酰胺为溶剂,3a～3g与2-氯乙酰胺在碱催化作用下,合成了7种吡唑酰胺类化合物4a～4g.其结构经～1H NMR,～（13）C NMR,IR,和HRMS表征.通过X射线衍射分析测定了化合物2-（6＇,6＇-二甲基-3＇-（4＇-甲氧基苯基）-4＇,5＇,6＇,7＇-四氢-5＇,7＇-桥亚甲基-吲唑-1＇-基）乙酰胺（4d）的晶体结构.探讨了化合物3a～3g和4a～4g的抑菌活性和对蚜虫的杀虫活性.实验结果表明,2-（6＇,6＇-二甲基-3＇-（4＇-氟苯基）-4＇,5＇,6＇,7＇-四氢-5＇,7＇-桥亚甲基-吲唑-1＇-基）乙酰胺（4g）既具有较好的抑菌效果,同时对紫薇蚜虫也表现出较好的杀虫活性.

英文摘要：

Novel pinanyl pyrazole derivatives were synthesized from nopinone and their bioactivities were also examined in this paper. The intermediate compounds 3-arylidenenopinones 2a～2g were synthesized by condensation of aromatic aldehydes and nopinone, and pinanyl pyrazole derivatives 3a～3g were subsequently obtained by cyclization and dehydroaromatization of compounds 2a～2g and hydrazine hydrate in the circumstance of N,N-dimethylformamide（DMT）. The target compound pinanyl pyrazole acetamide derivatives 4a～4g were synthesized by alkylation using 2-chloroacetamide as the alkylating agent under the condition of base catalysis. The structures of synthesized compounds were characterized by ～1H NMR, ～（13）C NMR, IR, HRMS, and X-ray diffraction analysis. Biological activities evaluation of compounds 3a～3g and 4a～4g were performed including antibacterial and insecticidal activities on Tinocallis kahawaluokalani. Test results showed that compound 4g was a more potent bactericide and fungicide than others because of its good activities against bacteria and fungi; furthermore, compound 4g had shown the better insecticidal activity against Tinocallis kahawaluokalani than the others.