中文摘要：

目的：探讨载药纳米粒联合光动力治疗应用于大鼠卵巢癌腹水瘤模型治疗的疗效。方法：制备包裹竹红菌乙素（HB）的聚氰基丙烯酸丁酯纳米粒（PBCA-NP）及建立Fischer 344大鼠卵巢癌腹水瘤模型。大鼠腹腔注射HB的DMSO溶液及HB-PBCA-NP溶液,观察不同药物剂型在大鼠体内分布,得到竹红菌乙素及竹红菌乙素纳米粒的药物动力学参数。将荷瘤大鼠随机分成4组：对照组未给予任何处理,手术组只接受手术治疗,实验组分别给予HB溶液及其纳米粒溶液,并接受手术及光动力治疗,观察生存时间。结果：纳米粒稳定,可用于体内实验。血清及肿瘤组织中,纳米粒组药物浓度达高峰的时间明显延迟。手术联合光动力治疗中位生存时间（95天和99天）比单纯手术（84天）长,可延长生存时间（P〈0.05）。结论：纳米粒可使药物在体内达到缓释,手术联合光动力治疗可延长生存时间。

英文摘要：

Objective： To investigate the therapeutic result of photodynamic therapy（ PDT） combined with nanoparticle delivery system applied to ovarian ascites tumor. Methods：Poly（ butyl cyanoacrylate） nanoparticles（ PBCA-NPS） wrapping hypocrellin B（ HB） were prepared and the Fischer 344 ovarian ascites tumor was established. Drugs were given to rats by injecting HB-DMSO or HB-PBCA-NP solution into peritoneal cavity. According to the distribution of the two delivery systems in vivo,pharmokinetics parameters of the drugs were calculated. The tumor-bearing rats were divided into four groups at random. Control group received no treatment,while the surgery group only received surgery. The experimental groups went on surgery and PDT after intraperitoneal injection of two kinds of drugs. Observe the survival time of four groups. Result： The nanoparticles were readily applied to experiment in vivo. The peak-reach time of drug entrapped in nanoparticles was put off compared with drug solution in both serum and tumor. Median survival time of experimental groups（ 95 d and 99d） were longer than surgery group（ 84 d）,P〈0. 05. Conclusions： Nanoparticles can achieve controlled release in vivo and surgery combined with PDT can prolong survival time.