中文摘要：

在努力的 50years 上，细胞的 reprogramming 为疾病建模和再生药打开一扇新门。尽管由抄写因素的 pluripotency 的正式就职变得普通，仅仅 epigenetic 修正的基本机制的小部分在这个过程期间被揭示了。清楚地理解 reprogramming 并且设计方法向 pluripotency 支持完整的转变，我们必须在不同 reprogramming 阶段从房间的全面描述获得卓见，它包含基因表示介绍，关键激活的染色质状态地图和压抑的标记，并且 DNA 修正。这里，我们与主要分子的管理者的一个焦点在 epigenetic reprogramming 考察最近的进展到 pluripotency 并且重视在揭开在未来研究位于这个唯一的平台的分子的机制下面的高产量的定序和系统的生物学途径的联合。

英文摘要：

Over 50 years of efforts, cellular reprogram- ruing opens a new door for disease modeling and regen- erative medicine. Although induction of pluripotency by transcription factors has become common, only a small portion of basic mechanisms of epigenetic modifications during this process have been revealed. To clearly under- stand reprogramming and devise ways to promote full transition towards pluripotency, we must gain insight from comprehensive characterizations of cells at distinct repro- gramming stages, which involves gene expression profil- ing, chromatin state maps of key activating and repressive marks, and DNA modifications. Here, we review recent advances in epigenetic reprogramming to pluripotency with a focus on the principal molecular regulators and attach importance to the combination of high-throughput sequencing and systematic biology approaches in uncov- ering underlying molecular mechanisms of this unique platform in future researches.