中文摘要：

目的利用复杂网络分析法探讨慢性右侧重度感音神经性耳聋（SNHL）患者静息态下全脑功能网络节点参数改变情况及可能存在的功能重组。方法选取2012年6月至2013年6月经广告招募及东南大学附属中大医院就诊的慢性右侧重度SNHL患者19例，性别、年龄匹配的健康受试者31名。在静息状态下采集各自的血氧水平依赖功能磁共振成像（BOLD-fMRI）数据，再构建90×90矩阵的全脑功能网络，计算网络节点相关参数：节点度（Nd）、节点介数（Nbi）、节点全局效率（NEglobal）和局部效率（NElocal）。通过双样本t检验及FDR校正观察两组间节点参数的差异情况。最后，将耳聋组差异有统计学意义的节点参数分别与耳聋持续时间、严重程度进行偏相关分析。结果在稀疏度范围为0．11～0．15时，大多数阈值下耳聋组左侧缘上回及右侧梭状回N。．均显著大于对照组（P〈0．05，FDR校正），而其余参数差异均无统计学意义；Nbi与耳聋时间及严重程度无相关性（P〉0．05）。结论长期右侧听力剥夺后，患者的听觉与语言、视觉等相关脑区可能发生了“交叉性”功能重塑。

英文摘要：

Objective To investigate the nodal properties and reorganization of whole-brain functional network in subjects with severe right-sided SNHL. Methods From June 2012 to June 2013, a total of 19 patients with severe right-sided SNHL were collected from Zhongda Hospital or the recruitment advertising along with 31 healthy controls. Based on the graph-theoretical analysis, the whole-brain functional networks were constructed using the BOLD-fMRI data of all subjects. Two sample two-tailed t-tests were used to investigate the differences between two groups in nodal metrics, such as node degree, node betweenness, node global efficiency and node local efficiency. All metrics were corrected by multiple comparisons. Partial correlation analysis was used to estimate the relationship between the significant metrics and the duration or severity of hearing loss. Results The right-sided SNHL showed significantly increased betweenness centrality in left supramarginal gyms and right fusiform. However, other nodal parameters showed no statistical difference. Besides, patients exhibited no significant association between the altered metrics and clinical variables. Conclusion Alterations of local topological properties may underlie cerebral cross-modal plastic reorganization in visual or speech-related regions in severe right-sided SNHL patients.