炎症性肠病(inflammatory bowel disease,IBD)包括克罗恩病(Crohn’s disease,CD)和溃疡性结肠炎(ulcerative colitis,UC),其病因和发病机制目前尚不清楚,近来研究显示肠道细菌参与IBD的发生。本文针对肠道菌群与IBD发病的相关性,以及肠道细菌移植在肠道疾病及代谢性疾病中的应用,探讨肠道细菌移植治疗IBD的应用前景。
Inflammatory bowel disease (IBD) includes Crohn's disease (CD) and ulcerative colitis (UC). The etiology and pathophysiology of IBD are still not clear. Recent evidences have shown that intestinal microbiota are involved in the patho- genesis of IBD. Based on the association with intestinal microbiota and the pathogenesis of IBD, and the utilization of fecal microbiota transplantation has been used in the management of intestinal diseases and metabolic diseases. This paper dis- cusses the application prospect of fecal microhiota transplantation in the treatment of IBD.