中文摘要：

目的合成一类新颖的、具有多药耐药逆转活性的细胞毒剂并对其细胞毒性进行初步研究。方法以N-苄基4-哌啶酮、苯甲醛衍生物为原料，通过羟醛缩合反应，以干燥的HCl气体为催化剂，20℃反应7～8h，用TCL检测反应进程，最后经重结晶得到目标化合物。结果合成了5种N-苄基-3，5-二（芳亚甲基）-4-哌啶酮衍生物，收率达到49％以上，采用1H-NMR、ESI—MS结合熔点对其结构进行了表征，并对其活性进行了初步的研究。结论该合成路线操作简便，反应条件温和，所得化舍物对几种肿瘤细胞具有良好的抑制作用。

英文摘要：

OBJECTIVE To synthesize a kind of novel cytotoxin with multi-drug-resistance reverting properties and study their cytotoxicity. METHODS The target compounds were obtained from N-benzyl-4-piperidones and benzaldehyde derivatives on the condition of 20℃ , 7 - 8 h, taking dry hydrogen chloride as catalyst, using aldol condensation reaction, inspected by TLC and purified through reerystallization. RESULTS Five N-benzyl-3,5-bis （arylmethylene） -4-piperidone derivatives were synthesized. The yield was over 49%. Their structures were characterized by 1H-NMR,ESI-MS with melting points. The data of cytotoxicity was obtained. CON- CLUSION The synthetic route is convenient and efficient ; The compounds had good inhibiting activity for a few kinds of tumor cells.