中文摘要：

目的：研究IgA肾病患者的动态血压特征,及其肾脏组织病理学改变与动态血压间的联系。方法：研究人员根据病史资料收集IgA肾病患者的一般临床资料;利用光学显微镜观察患者肾活检标本,并根据牛津分级标准对肾脏组织病理学指标进行分级;利用携带式的动态血压检测仪收集患者动态血压。结果：本研究共纳入54例非透析IgA肾病患者。与CKD1期的IgA肾病患者相比,CKD4、5期IgA肾病患者的24 hSBP、dSBP、nSBP均升高,且差异具有统计学意义（P〈0.05）,而24 hDBP、dDBP、nDBP无明显变化。M0与M1组患者的24 h动态血压无明显改变;与E0组患者相比,E1组患者的24 hSBP、dSBP、nSBP均升高,且差异具有统计学意义（P〈0.05）,而24 hDBP、dDBP、nDBP无明显改变;S0与S1组患者的24 h动态血压无明显改变;与T0组患者相比,T1/T2组患者24 hSBP、24 hDBP、dSBP、dDBP、nSBP、nDBP均升高,且差异具有统计学意义（P〈0.05）。结论：IgA肾病患者的24 h收缩压随着肾功能水平的下降而升高;肾小球毛细血管内皮细胞增生可能与24 h收缩压升高有关,肾间质纤维化/肾小管萎缩可能与24 h收缩压及24 h舒张压升高均有关。

英文摘要：

Objective： We aimed to investigate the characteristics of ambulatory blood pressure in patients with IgA nephrop- athy patients and to assess the relationship between ambulatory blood pressure and histopathologic findings in patients with IgA ne- phropathy. Methods： Patient＇ s basic characteristics were collected using their medical record. The renal biopsies were examined u- sing optical microscope, and the histopathologic findings were assessed using the Oxford Classification （ OC ） standard. Patients＇ blood pressure was measured using ambulatory blood pressure monitoring （ABPM）. Resuits：A total of 54 patients with non -dialysis IgA nephropathy were included in the study. Compared with CKD1 patients, the 24 hSBP,dSBP,nSBP were significantly higher in CKIM and CKD5 patients （P 〈 0.05 ）, while the difference of 24 hDBP,dDBP,nDBP was not significant. The 24 hSBP,dSBP,nSBP in E1 group were significantly higher than those in E0 group （P 〈 0.05 ）, and the 24 hSBP,24 hDBP,dSBP,dDBP, nSBP,nDBP in T1/T2 group were significantly higher those in T1/T2 group （P 〈 0.05）, while there is no significant difference of ambulatory blood pressure between SO and S1 group, or M0 and M1 group. Conclusion：The 24 hSBP increased with the renal function decline in pa- tients with IgA nephropathy. Tubular atrophy and interstitial fibrosis and arterial/arteriolar lesion may be associated with the increase of 24 h systolic blood pressure and diastolic blood pressure, glomerular capillary endothelial proliferation may be associated with the increase of 24 h systolic blood pressure.