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中文摘要：
在中枢神经系统存在一个由“脊髓-丘脑中央下核-腹外侧眶皮质（VLO）-导水管周围灰质一脊髓”组成的镇痛环路。阿片肽通过μ-阿片受体、5-羟色胺通过5-羟色胺1A、2和3受体、多巴胺通过D1和D2受体、GABA通过GABAA受体、谷氯酸通过NMDA受体、非-NMDA受体和代谢性谷氨酸受体参与介导VLO诱发的下行镇痛作用，它为阐明“脊髓-丘脑中央下核-VLO-导水管周围灰质．脊髓”痛觉调制环路的神经递质和受体机制提供了证据，具有重要的科学价值。
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