中文摘要：

目的进一步评估经皮肌肉电刺激（PMES）对尾部悬吊大鼠骨丢失的防护作用。方法17只雄性SD大鼠随机分为3组：自由对照组（Con）4只，尾吊组（TS）7只，尾吊且PMES组（TS＋PMES）6只。用频率50Hz且幅度3mA的电流对右侧臀中肌进行刺激，1h/d，共26d。实验结束后测量所有大鼠股骨近端、中段和远端的骨密度（BMD）。结果对于右侧股骨近端BMD，3组之间均无显著性差别。对于右侧股骨中段BMD，Con组与其它组都存在显著性差别（P〈0．05），而其它2组无显著性差别。对于右侧股骨远端BMD，TS组与其它组都存在非常显著的差别（P〈0．01），而其它2组无显著性差别。结论尾部悬吊大鼠股骨骨丢失发生在中段和远端，PMES可以对抗股骨远端的骨质疏松，保持正常的BMD。

英文摘要：

Objective To further evaluate the effects of percutaneous muscular electrical stimulation （PMES） against bone loss in tail-suspended rats. Methods Seventeen male SD rats were randomly divided into free control （Con） group （ n = 4）, tail-suspended （TS） group （ n = 7 ）, and tailsuspended and PMES （TS ＋ PMES） group （n =6）, The experiment lasted for 26 d with PMES 1 h/ d. The right gluteus medius muscle was stimulated by an electrical current with 50 Hz and 3 mA. Bone mineral density （BMD） of the proximal, middle and distal portions of femurs in all the rats were measured after experiment. Results For BMD of the proximal portion of right femurs, there were no significant differences among the three groups. For BMD of the middle portion of right femurs, there were significant differences between the Con group and the other groups （P 〈0.05）, while no significant difference between the other two groups. For the BMD of the distal portion of right femurs, there were extremely significant differences between TS group and the other groups （P 〈0.01 ）, while no significant difference between the other two groups. Conclusion Bone loss in tail-suspended rats occurs in the middle and distal portions of the femur, and PMES as a countermeasure against osteoporosis can keep BMD of the distal portion of the femur at a normal level.