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三种脂类物质对T细胞的影响
  • ISSN号：1674-7666
  • 期刊名称：《中国细胞生物学学报》
  • 时间：0
  • 分类：S858.31[农业科学—临床兽医学;农业科学—兽医学;农业科学—畜牧兽医] TS201.4[轻工技术与工程—食品科学;轻工技术与工程—食品科学与工程]
  • 作者机构：[1]南京大学医药生物技术国家重点实验室,南京210093
  • 相关基金：国家自然科学基金资助项目（No.30425009,No.30330530,No.30730030）
作者： 谢德[1], 华子春[1]
关键词： T细胞, N-3多不饱和脂肪酸, 溶血卵磷脂, 鞘氨醇-1-磷酸, T cell, n-3 poly unsaturated fatty acids, lysophosphatidylcholine, sphingosine 1-phosphate
中文摘要：

脂类物质作为细胞及细胞膜的一个重要组成部分,对于生物体有着重要影响。近年来,有关n-3多不饱和脂肪酸（n-3 PUFA）、溶血卵磷脂和鞘氨醇-1-磷酸等物质对T细胞影响的研究取得了重要进展,发现了n-3 PUFA具有免疫抑制的作用,而鞘氨醇-1-磷酸和溶血卵磷脂分别对T细胞因子的分泌、免疫稳态和T淋巴细胞进出循环系统有着重要影响。在此基础上,一些相关的生物活性物质被鉴定,并且有望开发成为有效的治疗药物。

英文摘要：

As one of the important components of cell and cell membrane, lipids play important roles in cell functions. Among these, scientists have made progresses in elucidating the effects of n-3 poly unsaturated fatty acids （n-3 PUFA）, lysophosphatidylcholine and sphingosine 1-phosphate on T cell. It has been discovered that n-3 PUFA has an effect of immune suppression, while, lysophosphatidylcholine and sphingosine 1-phosphate can impose important effects respectively on the secretion of cytokines, immune homeostasis and T lymphocyte egress into circulation system. Based on those, several kinds of bioactive substances have been identified, which have potentials of developing into effective therapeutic drugs.

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期刊信息
  • 《中国细胞生物学学报》
  • 中国科技核心期刊
  • 主管单位:
  • 主办单位:中国细胞生物学学会 中国科学院上海生命科学研究院 生物化学与细胞生物学研究所
  • 主编：郭礼和
  • 地址：上海岳阳路319号31A楼303室
  • 邮编：200031
  • 邮箱：CJCB@SIBS.AC.CN
  • 电话：021-54920950 54922892
  • 国际标准刊号：ISSN：1674-7666
  • 国内统一刊号：ISSN：31-2035/Q
  • 邮发代号:4-296
  • 获奖情况:
  • 国内外数据库收录:
  • 美国化学文摘（网络版）,中国中国科技核心期刊,中国北大核心期刊（2011版）
  • 被引量:2456