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中文摘要：
目的研究石榴皮多酚对痤疮主要致病菌——痤疮丙酸杆菌的抑制作用。方法首先用生长抑制试验（牛津杯法）确定石榴皮多酚醇提物对痤疮丙酸杆菌是否存在抑制作用,然后通过药基琼脂稀释法观察它对痤疮丙酸杆菌的MIC来评价该药物对所测细菌的抑制作用。结果石榴皮多酚醇提物500、300、100 mg/m L对痤疮丙酸杆菌ATCC11827具有较强的抑菌活性,其对痤疮丙酸杆菌的MIC为20 mg/m L。结论石榴皮多酚醇提物在体外具有明确的抑制痤疮丙酸杆菌活性的作用。
英文摘要：
Objective To study the inhibiting effect of pomegranate peel polyphenols on Propionibacterium acnes,the main pathogenic bacteria of acne. Methods First growth inhibition test（Oxford cup method） are used to determine the inhibiting effect of pomegranate peel polyphenols alcohol extract inhibition on P. acne. Then the inhibiting effect of drug to the test bacteria inhibition was evaluated through in vitro agar dilution method for observing the MIC of P. acne. Results Pomegranate peel polyphenols alcohol extract（500, 300, 100 mg/m L） showed strong antibacterial activity on P. acne ATCC11827, and its MTC to P. acne was for 20 mg/m L. Conclusion Pomegranate peel polyphenols alcohol shows a clear role in inhibiting the activity on P. acne in vitro.
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