中文摘要：

目的：研究退变性腰椎滑脱症需手术治疗患者术前Modic改变与椎间盘退变程度之间的关系。方法：2009年1月～2011年10月．腰椎滑脱症需手术治疗的患者44例，术前MRI对病变节段进行Modic分型，并用Pfirrmann分级和改良的Pfir-nnann分级评定病变节段椎间盘的退变程度：分析不同类型的Modic改变之间椎间盘退变分级的差异；评价Modic改变与椎间盘退变程度之间的关系。结果：44例患者中，12例无Modic改变，Pfirrmann分级为3．92±0．29，改良分级为5．92±0．90；ModicI型改变16例．Pfirrmann分级为4．31±0．60，改良分级为6．88±1．54；Modic1I型改变15例，Pfirrmann分级为4．27±0．46，改良分级为6．87±0．83；Modicm型改变1例，Pfirrmann分级为Ⅳ级和改良分级为6级。统计显示，ModicI、Ⅱ型与无改变组之间的Pfirrmanil分级与改良分级有显著性差异（P〈0．01）。ModicI型改变和Ⅱ型改变之间的Pfirrmann分级及改良分级均无显著性差异（P〉0．05）。ModicI型改变和无改变组之间、Ⅱ型和无改变组之间的改良Pfirrmann分级有统计学性差异（P〈0．05）。结论：在本组退变性腰椎滑脱症病例中，Modic改变与椎间盘退变Pfirrmann分级和改良分级之间有明确关联；ModicI型和Ⅱ型改变之间的Pfirrmann分级与改良分级无明显差别。

英文摘要：

Objective：To study the relationship between Modic changes and the degree of disc degeneration in patients with degenerative spondylolisthesis before surgery. Methods：From January 2009 to December 2011,44 cases of patients who had the degenerative spondylolisthesis were treated by operation. Preoperative MRI was performed to classify the Modie changes type. Pfirrmann grading assessment and modified Pfirrmann grading assessment were also perfomed. Then, the relationship between Modic changes and the degree of disc degeneration were analyzed in these patients with degenerative spondylolisthesis. Results：Among 44 cases, 12 cases had no Modic ehanges,Pfirralann grades were 3.92 ± 0.29,modified Pfirrmann grades were of 5.92± 0.90; 16 cases were Modie I type,Pfirrmann grades were 4.31 ±0.60,modified Pfirrmann grades were 6.88± 1.54; 15 cases were Modic type Ⅱ , Pfirrmann grades were 4.27 ±0.46,modified Pfirrmann grades were 6.87±0.83;Only 1 case of Modie type Ⅲ was found. Statistic analysis showed that modified Pfirrmann grades were significantly different between Modic I type group and no change group （P 〈 0.01）;Differences were also exsit between Modie Ⅱ type group and no change group （P 〈 0.01）;But,there was no significant difference between Modic I type group and Modie Ⅱ type group （P 〉 0.05）. Conclusion： In degenerative spondylolisthesis, there is a clear connection between the Modic changes and the degree of disc degeneration according to the Pfirrmann and modified Pfirrmann grading system assesment.