中文摘要：

目的研究短波长单色光对豚鼠的屈光发育和眼生物学参数的影响。方法 20只出生约2周的健康雄性豚鼠,随机分成两组（n=10）,分别在蓝光（430 nm）和白光（色温5000 K）下进行饲养。蓝光组为实验组,白光组为对照组,实验周期为12周。两种光照的光量子数均为每秒3×10-4μmol/cm2,测量光强度蓝光为0.527mW/cm2,白光为0.247 mW/cm2。实验前后均进行屈光度、角膜曲率、眼轴各部分长度的测量。结果实验前两组测量参数差异无显著性（P〉0.05）。光照12周后,蓝光组屈光度增加（1.20±0.66）D,白光组减少（1.18±0.85）D,蓝光组与白光组相比平均形成约2.40 D远视,统计学差异显著（P〈0.0001）;蓝光组眼轴和玻璃体腔分别增长（0.77±0.12）mm与（0.05±0.10）mm,白光组分别增长（0.95±0.18）mm与（0.21±0.13）mm。蓝光组的眼轴和玻璃体腔长度增长较白光组慢（P〈0.05）。但实验后两组角膜曲率半径、前房深度和晶状体厚度的变化差异无显著性（P〉0.05）。结论 430 nm短波长单色光诱导豚鼠眼轴和玻璃体腔长度延长较慢,产生远视。

英文摘要：

Objective To investigate the effect of short-wavelength monochromatic light on refractive development and eye growth in guinea pigs.Methods Twenty male two-week old guinea pigs were randomly distributed into two groups（n=10 in each group）： blue-light group（BL） and white-light group（WL）.The BL group was raised under 430 nm monochromatic light,and the WL group was reared under white light with 5000 K color temperature.The light quantum number of the two groups was identical,3×10-4 μmol·cm-2·s-1.The irradiance value was 0.527 mWcm-2 of blue light and 0.247 mWcm-2 of white light approximately.Biometric and refractive measurements were performed before and after treatment.Results Before treatment,the differences between the biometric parameters of the two groups including refraction,corneal curvature and axial components were not significant（P0.05）.After 12-week exposure,the refraction increased 1.20±0.66 D in the BL group,and decreased 1.18±0.85 D in the WL group.There was a 2.40 D hyperopia in the BL group when compared with that of the WL group（P0.0001）.Meanwhile,the axial length and vitreous body grew 0.77±0.12 mm and 0.05±0.10 mm in the BL group,respectively,and they were extended by 0.95±0.18 mm and 0.21±0.13 mm,respectively,in the WL group.There was a slower speed of axial growth and vitreous body＇s extension when compared with that of the control group（P0.05）.No significant differences were found between groups at the end of the research in the radius of corneal curvature,depth of anterior chamber and lens thickness（P0.05）.Conclusions 430 nm short wavelength monochromatic light can slow down the prolongation of axial length and vitreous body and induce hyperopia in guinea pigs.