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中文摘要：
目的 探讨C臂锥形束CT成像时间对脑血管成像图像质量及辐射剂量的影响.方法 采用PBU-60型CT头部仿真体模,行C臂锥形束CT成像.分别设置成像时间为5、8和20 s,采用每个成像时间对体模进行3次成像,并将不同成像时间获得的图像进行VR、MIP和MPR重组.分别测量不同成像时间下颈内动脉颅内段、大脑中动脉、大脑前动脉及邻近脑组织的噪声、信噪比（SNR）和对比噪声比（CNR）,并采用单因素方差分析进行比较.对不同成像时间下颈内动脉颅内段、大脑中动脉、大脑前动脉各重组图像的图像质量进行主观评分,并采用秩和检验进行比较.记录不同成像时间的剂量面积乘积（DAP）和有效剂量（ED）,并采用方差分析进行比较.结果 C臂锥形束CT20 s成像颈内动脉颅内段、大脑中动脉、大脑前动脉的SNR值分别为22.29±1.41、29.36±0.11和23.13±2.10,5s分别为13.83±0.61、14.65±0.16和12.79±0.19,8s分别为14.92±0.96、18.97±1.24和16.65±0.46,差异均有统计学意义（F值分别为58.19、327.29和52.74,P均＜0.01）.20 s时的CNR值高于5s及8s时的CNR,颈内动脉颅内段、大脑中动脉、大脑前动脉及相应血管邻近均匀脑组织的噪声值低于5s及8s,差异均有统计学意义（P均＜0.01）.C臂锥形束CT5 s、8s及20 s VR图像主观评分分别为（3.61±0.49）、（4.06±0.53）和（4.72±0.45）分,MIP图像主观评分分别为（3.42±0.50）、（3.83±0.65）和（4.50±0.51）分,MPR图像的主观评分分别为（2.83±0.45）、（3.14±0.35）和（3.67±0.49）分,差异均有统计学意义（x2值分别为51.29、42.25和43.56,P均＜0.01）.C臂锥形束CT5 s、8s及20 s脑血管成像的DAP值分别为（9.11±0.18）、（13.81±0.75）和（58.62±0.62）Gy·cm2,ED值分别为（0.91±0.02）、（1.38±0.75）和（5.84±0.11）mSv,差异均有统计学意义（F值分别为3 720.30和3 654.85,P均＜0.01）.结论 成像时间与C臂锥形束CT脑血管成像的?
英文摘要：
Objective To investigate the influence of acquisition time of C-arm cone-beam CT on image quality and radiation dose of cerebral angiography.Methods C-arm cone-beam CT of cerebral angiography was performed on the male anthropomorphic head phantom,with DynaCT imaging mode and the acquisition time of 5 s,8 s and 20 s were used.Scanning was performed with each acquisition time for three times,and VR,MIP and MPR images were reconstructed.The attenuation values and their standard deviations of intracranial segment of the internal carotid artery （ICA）,middle cerebral artery（MCA）,anterior cerebral artery（ACA） and uniformed brain tissues were measured to calculate the image noise,signal to noise ratio （SNR） and contrast to noise ratio （CNR）.We used the image noise,SNR and CNR as the objective standard to evaluate the image quality,and One-way ANOVA analysis of variance was used to assess the difference among them.A scale with scores 1 to 5 was used to rate the quality of the reconstructed image of ICA,MCA,ACA as a subjective evaluation,the difference among the evaluation scores were analyzed using Kruskal-wallis.We recorded the dose area product （DAP） of each acquisition time and the effective dose（ED） was calculated to assess the radiation dose,the difference among them were analyzed using One-way ANOVA analysis of variance.Results In C-arm cone beam CT 20 s imaging,the SNR of intracranial segment of the ICA,M CA,ACA were 22.29± 1.41,29.36 ±0.11 and 23.13 ±2.10 respectively,in 5 s imaging13.83 ±0.61,14.65 ±0.16 and 12.79±0.19 respectively,in 8 s imaging 14.92±0.96,18.97 ± 1.24 and 16.65 ±0.46 respectively,all the results showed a significant difference （F valued 58.19,327.29,52.74 respectively,all P valued＜0.01）,the CNR of 20 s imaging were higher than that of 5 s and 8 s imaging,the Noise of ICA,MCA,ACA and the uniformed brain tissues of 20 s imaging were lower than that of 5 s and 8 s imaging,all the results showed significant difference （all P valued＜0.01）.The subjecti
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