中文摘要：

目的探讨作为5-羟色胺（5-HT）重要来源的肠嗜铬细胞（EC细胞）在功能性消化不良（FD）患者胃黏膜中的改变。方法对15例健康志愿者和33例FD患者进行研究，免疫组化法染色并计数EC细胞。电镜观察EC细胞超微结构。结果FD患者近端胃黏膜EC细胞数显著高于对照组（12．5±2．1比8．3±1．4，t=2．353，P〈0．05）。FD患者EC细胞染色强度较对照组明显增强（3．72±0．42比2．61±0．57，t=2．078，P〈0．05）。随胃黏膜炎症程度的加重，EC细胞数量增加，染色强度增强。电子显微镜下EC细胞内高尔基体、线粒体及内质网较多，胞质内有特异性分泌颗粒。结论EC细胞可能参与FD发病。EC细胞数量与胃黏膜炎症程度有关。

英文摘要：

Objective To investigate the alteration of serotonin-producing gastric enterochromaffin （EC） cell in patients with functional dyspepsia （FD）. Methods ＂Fifteen healthy volunteers and 33 patients with FD were enrolled. Proximal gastric mucosal EC cells were countered after immunohistochemistry staining. The ultrastructure of EC cell was observed by electromicroscope. Results The EC cells in proximal gastric mucosa in patients with FD were significant higher than that in controls （12.5 ± 2.1 vs 8.3± 1.4, t = 2. 353, P 〈 0.05）, and the staining intensity of EC cell in patients with FD was also stronger than that in controls （3.72±0. 42 vs 2.61 ±0.57, t = 2. 078, P〈 0. 05）. The more sever the gastric mucosal inflammation was, the more number of EC cells and the stronger staining intensity were. Under the electromicroscopy, more Golgi apparatus, mitochondria and endoplasmic reticulum were found in EC cells. Special secreting particles were also found in cytoplasm. Conclusions EC cells may be involved in the pathogenesis of FD. The number of EC cell is related with the severity of gastric mucosal inflammation.