中文摘要：

目的探讨冠心病(CAD)患者糖化血清白蛋白(GA)的表达水平及其相关性。方法选择该院2011年1月至2012年12月内科住院患者124例,分为CAD与非CAD组,检测并比较两组GA、糖化血红蛋白(Hb A1c)、餐后2 h血糖(2 h PG)等指标。CAD的诊断采用冠状动脉造影。应用Logistic回归分析GA的独立危险性。结果检出CAD患者82例(66.13%),其GA、2 h PG、Hb A1c水平均高于对照组(P<0.05)。亚组分析显示,正常糖耐量组CAD患者GA明显较高(P=0.006);冠状动脉单支病变和多支病变者GA水平均高于无CAD者(P=0.028,0.043);高血糖组亚组分析结果同正常糖耐量组。Logistic多因素回归分析显示,在所有对象和不同亚组分析中,GA均是CAD的独立危险因素(P<0.05)。结论GA在高血糖或者正常糖耐量水平的CAD患者中均明显升高,是CAD发生的独立危险因素。

英文摘要：

Objective To investigate the expression of glycated albumin in patients with coronary artery disease ( CAD) and their correlation.Methods 124 patients were divided into CAD and non-CAD groups according to the diagnostic criteria of coronary angiography. And then, the levels of glycated albumin (GA), glycosylated hemoglobin (HbA1c), postprandial 2 h plasma glucose (2 h PG) psychosis indicators were compared between two groups.Results CAD was occurred 66.13%(82/124) .The levels of GA, 2 h PG, HbAlc in CAD group were higher than those in non-CAD group(all P<0.05).In the subgroup of normal glucose tolerance group, CAD patients had a high level of GA than that of non-CAD patients(P=0.006).The level of GA was higher in CAD patients with one vessel (P=0.028) and multi-vessel lesions(P=0.043) than that in non-CAD groups; the similar results obtained in hyperglycemia group.GA was an independent risk factor of CAD among all subjects (P<0.05).Conclusions The level of GA becomes elevated in CAD patients with normal glucose tolerance or hyperglycemia.And it is an independent risk factor of CAD.