中文摘要：

我们这里考察多功能的酶的新奇心脏的保护的效果，激活 p21 的 kinase 1 (PAK1 ) ，一个 serine/threonine 蛋白质 kinase 家庭的一个成员。尽管有从在 noncardiac 组织的研究的证据的大身体，显示那项 PAK1 活动在很多细胞的功能的规定是关键的，在心的 PAK1 的角色仅仅在过去几年被揭示了。在这评论，我们在在心发信号的 PAK1 上装配最近的调查结果的概述，特别地它的心脏的保护的效果。我们在场为表明那的 PAK1 的一个模型为明确地影响在哪个蛋白质 phosphorylation 的规定由蛋白质磷酸酶 2A ( PP2A )说 predominates.We 的心脏的细胞的过程提供机制讨论反肾上腺素能并且 antihypertrophic PAK1 的心脏的保护的效果，象它在维持室的 Ca 的角色一样<啜class=“ a-plus-plus ”>2+动态平衡和 electrophysiological 稳定性在下面生理，肾上腺素能并且 hypertrophic 压力条件。

英文摘要：

We review here the novel cardiac protective effects of the multifunctional enzyme, p21-aetivated kinase 1 （PAK1）, a member of a serine/threonine protein kinase family. Despite the large body of evidence from studies in noncardiac tissue indicating that PAK1 activity is key in the regulation of a number of cellular functions, the role of PAK1 in the heart has only been revealed over the past few years. In this review, we assemble an overview of the recent findings on PAKI signaling in the heart, particularly its cardiac protective effects. We present a model for PAK1 signaling that provides a mechanism for specifically affecting cardiac cellular processes in which regulation of protein phosphorylation states by protein phosphatase 2A （PP2A） predominates. We discuss the anti-adrenergic and antihypertrophic cardiac protective effects of PAK1, as well as its role in maintaining ventricular Ca2＋ homeostasis and electrophysiological stability under physiological, β-adrenergic and hypertrophic stress conditions.