报道一种以间苯二酚为起始原料,通过傅一克酰基化、成吡喃环、羟醛缩合、氧化-重排-关环等五步反应,简洁、高效地合成天然吡喃异黄酮Barbigerone及其类似物的方法.该方法不仅原料易得、价格低廉、操作简单、条件温和。而且可得高达24%-30%的总收率.
A concise and highly efficient protocol for the synthesis of barbigerone and its structural analogues is reported. Resorcinol was converted to the final products via Friedel-Crafts reaction, pyranoid ring formation, aldol reaction, and oxida- tion-rearrangement-cyclization with 24%-30% overall yields.