中文摘要：

肿瘤徽环境与肿瘤发生发展密切相关。最近的研究证实，肿瘤形成可能是干细胞分化异常导致。而微环境是于细胞稳态调节的关键，干细胞微环境的失调在肿瘤发生中扮演了重要角色。而在肿瘤发展过程中，适宜的微环境将促进肿瘤快速增殖，改变这些特异的微环境可以抑制肿瘤的恶性表型。同时，在肿瘤迁移过程中，微环境也起到了重要作用。这些机制的研究有助于加深对肿瘤的认识，为肿瘤的预防和治疗提供新的理论基础。

英文摘要：

Toumor microenvironment is closely related to the development and progression of tumors. Recently, researchers suggest that abnormal differentiation of stem cells might lead to the initiation of cancer. Microenvironment is the key to homeostatic regulation of stem cells. Disregulation of microenvironment plays an important role in the carcinogenesis. And during the development of tumor,a suitable microenvironment can promote the rapid proliferation of tumor. Changing the specific microenvironment can suppress the tumorigenic phenotype of aggressive cancer. Meanwhile, microenvironment also plays an essential role in cancer metastasis. Understanding of these underlying mechanisms will enhance our knowledge of cancer and will provide a novel basis for prevention and treatment of cancer.