中文摘要：

地方性砷中毒是一种复杂的全身性损害疾病，但目前其机制及防治研究多针对砷致某器官损害单兵作战，通盘考虑砷中毒全身性损害问题不足，故难以从根本上解决问题。近年来，免疫学领域的一系列令人瞩目的研究成果为长期困扰人类的多种复杂性疾病致病机制的阐明做出了重大贡献。亦为其预防和治疗带来了新的曙光。因此，从免疫学角度深化认识砷所致的全身性损害，有望在进一步揭示砷致多器官损害机制、更具针对性地采取合理有效的防治措施等方面获得突破性进展。

英文摘要：

Endemic arsenicosis is a disease with complex systemic damage, but the mechanism and its control strategy are mostly focused on a single organ or system damage caused by arsenic, and the systemic damage of arsenic exposure remains not fully understood. In recent years, considerable progress has been made in the field of immunology, which made an important contribution for the pathogenic mechanism of various complex diseases, and also brings a new dawn for its prevention and treatment. In consequence, a breakthrough progress is expected to make in aspects of the mechanism and its control strategy of arsenic caused systemic damage from the perspective of immunology.