中文摘要：

秀丽隐杆线虫在遗传背景、研究手段上具有其独特的优势，以它为模型的研究集中于生命科学和医学研究的多个领域，阿尔茨海默病（AD）的研究也列于其中。虽然它神经系统结构简单，但它神经元的功能和神经递质都与其他动物类似，是研究神经退行性疾病机制的良好在体模型。本文就秀丽隐杆线虫在AD的研究进展进行了综述，主要包括AD相关基因在秀丽隐杆线虫中的保守性、AD相关基因转基因模型及其在研究治疗AD药物上的应用。

英文摘要：

Caenorhabditis elegans （C. elegans） is an important model organism for biology and medicine research because it is simple, easy to deal with and many human disease related genes could be found in it. The structure of the nervous system in C. elegans is very simple, whereas its neuronal cell types and corresponding neurotransmitters resemble that in mammals. Thus C. elegans is one of the good kinds of models in vivo for the research of neurodegenerative disease including Alzheimer disease. This article reviewed the progress of the applications of C. elegans as a model in Alzheimer diseases research.